arXiv:2605.11303v1 Announce Type: new Abstract: We investigate the use of Large Language Models (LLMs) for zero-shot prediction of Ryff Psychological Well-Being (PWB) scores from spontaneous speech. Using a few minutes of voice recordings from 111 participants in the PsyVoiD database, we evaluated 12 instruction-tuned LLMs, including Llama-3 (8B, 70B), Ministral, Mistral, Gemma-2-9B, Gemma-3 (1B, 4B, 27B), Phi-4, DeepSeek (Qwen and Llama), and QwQ-Preview. A domain-informed prompt was developed in collaboration with experts in clinical psychology and linguistics. Results show that LLMs can extract semantically meaningful cues from spontaneous speech, achieving Spearman correlations of up to 0.8 on 80\% of the data. Additionally, to enhance explainability, we conducted statistical analyses to characterise prediction variability and systematic biases, alongside keyword-based word cloud analyses to highlight the linguistic features driving the models' predictions.